What We Do
The Center for Network Systems Biology at Boston University supports ambitious research initiatives to map protein interaction networks in different biomedical contexts. CNSB provides essential interdisciplinary knowledge as well as the technical prowess to get to the heart of network systems biology. With collaborative research programs based across both Boston University campuses – BU Medical Center and Charles River – the CNSB will serve as a leading hub from which to chart the dynamic molecular networks critical to human cells and tissues.
Human health and development depend on dynamic networks of physical, and functional, interactions between proteins. However, the details of these networks – how they are formed and how they function – are largely unknown. More importantly, and perhaps surprisingly, it is still unclear how these networks malfunction in disorders like cancer, neurodegeneration or cardiovascular disease.
The CNSB aims to advance fundamental understanding of the molecular mechanisms governing human health and development, basic cell biology, and normal protein function. Since the disruption of protein interactions underlies many pathologies, these studies will also reveal causal disease relationships and druggable targets, helping to advance precision medicine.
A talented team of researchers at the Center is developing and deploying innovative ‘functional proteomic’ methods. These methods combine protein biochemistry, precision mass spectrometry, and molecular genetics together with integrative statistically-motivated computational approaches to systematically characterize the myriad of protein interactions present inside cells and tissues.