CENTER FORNETWORK SYSTEMSBIOLOGY
What We Do
Human health and development depend on dynamic networks of physical, and functional, interactions between proteins. However, the details of these networks – how they are formed and how they function – are largely unknown. More importantly, and perhaps surprisingly, it is still unclear how these networks malfunction in disorders like cancer, neurodegeneration or cardiovascular disease.
The CNSB aims to advance fundamental understanding of the molecular mechanisms governing human health and development, basic cell biology, and normal protein function. Since the disruption of protein interactions underlies many pathologies, these studies will also reveal causal disease relationships and druggable targets, helping to advance precision medicine.
A talented team of researchers at the Center is developing and deploying innovative ‘functional proteomic’ methods. These methods combine protein biochemistry, precision mass spectrometry, and molecular genetics together with integrative statistically-motivated computational approaches to systematically characterize the myriad of protein interactions present inside cells and tissues.