Center for Network Systems Biology — Boston University

Databases & Links
Public Data

The CNSB's research has contributed to valuable public datasets used in the fields of proteomic profiling and protein complex characterization. These datasets catalogue such diverse sample classes as mammalian tissues, unicellular organisms, and viral proteins.

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Website Urls/Links

Network systems biology – the study of the physical and functional interactions of biomolecules in diverse complex biological systems that are crucial to health and disease – is an emerging strength at Boston University.

Elucidating the biological networks that drive normal development and pathology is fundamental to a deeper mechanistic understanding of biological processes and their causal links to clinical disorders. Network systems biology is expected to drive biological research in the coming decades.

SARS-CoV-2 proteome

SARS-CoV-2 Infection in iAT2 cells

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Hekman et al. (2020)

Mouse proteome

Mouse brain

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi et al. (2020)

Mouse heart

Comparative Proteomics Profiling of a Phospholamban Mutant Mouse Model of Dilated Cardiomyopathy Reveals Progressive Intracellular Stress. Gramolini et al. (2008)

Mouse tissue

Global Survey of Organ and Organelle Protein Expression in Mouse: Combined Proteomic and Transcriptomic Profiling. Kislinger et al. (2006)

Human Proteome

TGFβ induced EMT

A multi-tiered map of EMT defines major transition points and identifies vulnerabilities. Paul et al. (2021) (pending submission)

Metazoan complexes

E. coli proteome

Soluble proteins eNet

Global Functional Atlas of Escherichia coli Encompassing Previously Uncharacterized Proteins. Hu et al. (2009)

eSGA

Quantitative genome-wide genetic interaction screens reveal global epistatic relationships of protein complexes in Escherichia coli. Babu et al. (2014)

eMaps – Cell Envelope

Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways. Babu et al. (2011)

eMaps – Protein Synthesis

Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery. Gagarinova et al. (2016)

Yeast proteome

Legacy websites

Project databases