Center for Network Systems Biology — Boston University

Members:
Core & Affiliated Faculty

The CNSB has forged extensive links to numerous research faculty and associated educational initiatives at institutions such as MIT, and across both BU campuses, including the new Faculty in Computing and Data Sciences and the Graduate Program in Bioinformatics, both premier cross-campus mentoring venues at BU.

Professor Andrew Emili
Professor Andrew Emili - Director of CNSB
The Founding Director of CNSB, Professor Andrew Emili, is an international authority in mapping molecular interaction networks using advanced experimental and computational methods. He was recruited to Boston University (BU) in 2017 through the Provost’s Senior Faculty Hiring Initiative aimed at attracting exceptional researchers to BU.

Education

After receiving his PhD in Molecular and Medical Genetics from the University of Toronto in 1997, Professor Emili pursued post-doctoral studies as a Damon Runyon/Walter Winchell Research Fellow with the Nobel Laureate Leland Hartwell at the Fred Hutchison Cancer Research Center in Seattle. During this time, he also learnt protein mass spectrometry with John Yates III at the University of Washington.

Research Activity

In 2000, Professor Emili established his own laboratory in Toronto. During his time there, he developed and applied innovative proteomics, functional genomics and bioinformatics methods to investigate biological systems and molecular association networks in human cells and model organisms. In particular, he focused on quantitative, high precision mass spectrometry to characterize protein complexes in a comprehensive, high-throughput manner. The expertise he has developed in this area was one of the reasons he was recruited to head up the CNSB – his experience with state-of-the-art technology is evident in the focus of the Center.

Professor Andrew Emili
Professor Andrew Emili - Director of CNSB

Publications

Professor Emili has published >250 papers with >40,000 citations (h-index 82), including genome-wide studies of soluble and membrane protein complexes in yeast (Cell 2005; Nature 2006; Mol Cell 2004; Nature 2012), E. coli (Nature Biotech 2018, Nature 2005; PLoS Biol 2009), and human cells (Cell 2012; Cell Rep. 2014), documenting hundreds of protein interactions, multi-subunit complexes and molecular pathways linked to core biological processes and human disease.

Other Interests

Professor Emili’s influence is widely recognized, and his group’s data is often accessed via public databases. He reviews regularly for prominent journals such as Cell and Nature, while serving on national and international grant review panels. Professor Emili was also editor of “Network Biology” and “Systems Analysis” books with >40,000 downloads, and has given >200 talks at research conferences, international symposia and workshops.

Affiliated Faculty Members:

Peter Ash

Peter Ash

PhD, Research Assistant Professor in the Pharmacology & Experimental Therapeutics department at the Boston University School of Medicine
Field of Study:
Molecular biology of neurodegeneration
Aaron Beeler

Aaron Beeler

PhD, Associate Professor
Biomedical Engineering
Field of Study:
Schizophrenia, Parkinson’s, Cystic fibrosis

Marcus Bosmann

MD, Associate Professor of Medicine, Pathology & Laboratory Medicine
Field of Study:
Acute respiratory distress syndrome
Cynthia Bradham

Cynthia Bradham

PhD, Associate Professor of Biology
Field of Study:
Developmental biology; Embryonic pattern formation; Systems biology
Esther Bullitt

Esther Bullitt

PhD, Associate Professor, Physiology & Biophysics
Field of Study:
B acterial adhesion pili (fimbriae), type III secretion system needles, and virus replication
Cifuentes

Daniel Cifuentes

PhD, Assistant Professor of Biochemistry
Field of Study:
Embryonic programming, developmental biology
Cathy Costello

Cathy Costello

PhD, William Fairfield Warren Distinguished Professor; Director ,Center for Biomedical Mass Spectrometry
Field of Study:
Biopolymer structural studies; development of mass spectral methods
Mark Crovella

Mark Crovella

(CS), PhD, Professor and former Chair in the Department of Computer Science
Field of Study:
Computer networking and network science
Cruz Martin

Alberto Cruz – Martin

PhD, Assistant Professor of Biology
Field of Study:
Neural circuits, Cognitive function, Neurodevelopmental disorders
Davey

Robert Davey

PhD, Professor of Microbiology
Field of Study:
Microbiology
Sarah Davies

Sarah Davies

PhD, Assistant Professor, Biology
Field of Study:
ecological genomics, population genetics, molecular ecology, coral ecology, climate change, symbiosis
Gerald Denis

Gerald Denis

PhD, Associate Professor of Pharmacology and Medicine; Co - Director, BU - BMC Cancer Center Education
Field of Study:
Molecular oncology, chromatin control of transcription in cancer
Rachel Fearns

Rachel Fearns

PhD, Professor , Microbiology
Field of Study:
Transcriptional and genome replication mechanisms of non - segmented negative strand RNA viruses
Juan Fuxman Bass

Juan Fuxman Bass

PhD, Assistant Professor, Biology
Field of Study:
Immune regulation, gene regulatory networks, systems biology, disease mutations, inflammation, transcription factors
David Harris

David Harris

MD - PhD, Professor and Chair of Biochemistry
Field of Study:
Neurodegenerative disorders, prions, and Alzheimer’s disease
Angela Ho

Angela Ho

PhD, Associate Professor , Biomedical Engineering
Field of Study:
Molecular and cellular basis of synaptic function in neurodevelopment and neurodegenerative disease
Khalil Mo

Ahmad Mo Khalil

MS, Ph D, Associate Professor, Biomedical Engineering
Field of Study:
Developing synthetic biology approaches to illuminate and control eukaryotic transcriptional regulation, chromatin/epigenetic regulatory systems, and protein aggregation systems

Darrell Kotton

MD/PhD, David C. Seldin Professor in the Departments of Medicine, Pathology and Laboratory Medicine; founding Director of the Center for Regenerative Medicine
Field of Study:
iPSC biology and lung development, disease, and regeneration
Kim Mcall

Kim Mcall

PhD, Professor and Chair , Biology
Field of Study:
Drosophila developmental biology, cell death, oogenesis
Mark McComb

Mark McComb

PhD, Research Associate Professor, Biochemistry
Field of Study:
Mass spectrometry, proteomics, biomarkers, post - translational modifications, PTMs, bioinformatics
Stefano Monti

Stefano Monti

PhD, Associate Professor of Medicine and Biostatistics
Field of Study:
Computational Biomedicine and network inference
Elke Muhlberger

Elke Muhlberger

PhD, Associate Professor of Microbiology; Investigator, NEIDL
Field of Study:
Ebola (EBOV) and Marburg virus (MARV) and host pathogenesis.
Valentina Perissi

Valentina Perissi

PhD, Associate Professor, Biochemistry; Co - PI and Director, Boston Nutrition Obesity Research Center
Field of Study:
Epigenetics, Endocrinology and Metabolism.
John Porco

John Porco

PhD, Director, Center for Molecular Discovery; Co - Director (w / A. Emili) of the BU Target Discovery Laboratory
Field of Study:
Chemical synthesis of bioactive compounds.
Qiu

Wendy Qiu

MD, PhD , Professor, Psychiatry ; Professor, Pharmacology & Experimental Therapeutics
Field of Study:
Dementia, Geriatric Psychiatry
Mohsan Saeed

Mohsan Saeed

PhD, Assistant Professor of Biochemistry; Investigator, NEIDL
Field of Study:
Systems biology of host – virus interface and biochemistry of viral proteases.
Daniel Segre

Daniel Segrè

PhD, Professor of Bioengineering
Field of Study:
Structural bioinformatics.
Trevor Siggers

Trevor Siggers

PhD, Associate Professor of Biology; Member of the Nanotechnology Innovation and the Biological Design Center
Field of Study:
Systems biology and regulation of immune system and inflammatory responses.
Sandor Vajda

Sandor Vajda

PhD, Professor of Bioengineering
Field of Study:
Structural bioinformatics.
Bob Varelas

Xaralabos (Bob) Varelas

PhD; Associate Professor of Biochemistry
Field of Study:
Molecular mechanisms of cell proliferation, differentiation and survival during development and disease
David Waxman

David Waxman

PhD, Professor , Biology, Medicine, Biomedical Engineering
Field of Study:
Genomic and epigenetic mechanisms controlling liver gene expression; molecular endocrinology and cell signaling through transcriptional networks; role of angiogenesis and innate immune system in cancer therapy and pha rmacology; nuclear receptors and responses to environmental chemicals
Andrew Wilson

Andrew Wilson

MD, Assistant Professor of Medicine, Director of the Alpha - 1 Center
Field of Study:
Molecular Pulmonology.
Wolozin

Benjamin Wolozin

MD/PhD, Prof. Pharmacology & Neurology
Field of Study:
Molecular biology of neurodegeneration.
Joe Zaia

Joseph Zaia

PhD, Professor of Biochemistry
Field of Study:
Glycoproteomics of the cell surface and extracellular matrix.

The CNSB has forged extensive links to numerous research faculty and associated educational initiatives at institutions such as MIT, and across both BU campuses, including the new Faculty in Computing and Data Sciences and the Graduate Program in Bioinformatics, both premier cross-campus mentoring venues at BU.