Molecular biology of neurodegeneration
After receiving his PhD in Molecular and Medical Genetics from the University of Toronto in 1997, Professor Emili pursued post-doctoral studies as a Damon Runyon/Walter Winchell Research Fellow with the Nobel Laureate Leland Hartwell at the Fred Hutchison Cancer Research Center in Seattle. During this time, he also learnt protein mass spectrometry with John Yates III at the University of Washington.
In 2000, Professor Emili established his own laboratory in Toronto. During his time there, he developed and applied innovative proteomics, functional genomics and bioinformatics methods to investigate biological systems and molecular association networks in human cells and model organisms. In particular, he focused on quantitative, high precision mass spectrometry to characterize protein complexes in a comprehensive, high-throughput manner. The expertise he has developed in this area was one of the reasons he was recruited to head up the CNSB – his experience with state-of-the-art technology is evident in the focus of the Center.
Professor Emili has published >250 papers with >40,000 citations (h-index 82), including genome-wide studies of soluble and membrane protein complexes in yeast (Cell 2005; Nature 2006; Mol Cell 2004; Nature 2012), E. coli (Nature Biotech 2018, Nature 2005; PLoS Biol 2009), and human cells (Cell 2012; Cell Rep. 2014), documenting hundreds of protein interactions, multi-subunit complexes and molecular pathways linked to core biological processes and human disease.
Professor Emili’s influence is widely recognized, and his group’s data is often accessed via public databases. He reviews regularly for prominent journals such as Cell and Nature, while serving on national and international grant review panels. Professor Emili was also editor of “Network Biology” and “Systems Analysis” books with >40,000 downloads, and has given >200 talks at research conferences, international symposia and workshops.
The CNSB has forged extensive links to numerous research faculty and associated educational initiatives at institutions such as MIT, and across both BU campuses, including the new Faculty in Computing and Data Sciences and the Graduate Program in Bioinformatics, both premier cross-campus mentoring venues at BU.