Center for Network Systems Biology — Boston University

Research
Innovative Multidisciplinary Strategies

CNSB will continuously develop and apply innovative multidisciplinary strategies to identify macromolecules of broad biomedical significance. These include powerful integrative computational approaches to combine our proteomic data with complementary genomic and metabolomic information.

CNSB generates ground-breaking probabilistic molecular interaction “maps” to define the roles and associations of the many new protein complexes we discover: we pay particular attention to their functional significance in normal and disease states.
Together, the innovative tools, training, and datasets created by the CNSB will serve as valuable resources for the broader scientific community. By drawing together an outstanding team of experts in network biology, systems biology, molecular biology, chemical biology, genomics, and computational modelling, the CNSB aims to create a world class platform for exploring molecular networks and their links to human health and disease.
Ben Mass Spec
Mass Spectrometer Cleaning

Sharing Protocols

FAIMS

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Expansion Microscopy

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Solid Phase Micro Extraction

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Desalting

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Operating Agilent HPLC

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Tissue Homogenization

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Zip Tip Desalting

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Notable publications by center members include:

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2.

Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and ...

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.

Connectivity webs mediate the unique biology of the mammalian brain.

A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.

Individual variation in the addiction liability of amphetamines has a heritable genetic component. We previously identified Hnrnph1 (heterogeneous nuclear ...